It is resistant to some forms of extended-spectrum beta-lactamase. MERREM IV should be given as intravenous infusion over 30 minutes. -Hematologic: Hematopoietic organ system functions (periodically during prolonged therapy) Abstract & Commentary . There is inadequate information regarding the use of MERREM IV in patients on hemodialysis or peritoneal dialysis. -Recommended as an alternative therapy. Approximately 70% (50% to 75%) of a meropenem dose administered intravenously is recovered unchanged in the urine over 12 hours 1. Infants and children: 40 mg/kg IV every 8 hours Dosage should be reduced in patients with creatinine clearance of 50 mL/min or less. Maximum dose: 1 g/dose CrCl >60 mL/min: No dosage adjustment necessary; CrCl 21-60 mL/min: 260 mg/day PO; CrCl ≤20 mL/min or continuous peritoneal dialysis : 200 mg/day PO; Dosing Considerations Uses: As a single agent therapy for the treatment of complicated intraabdominal infections (including appendicitis and peritonitis) due to viridans group streptococci, E coli, Klebsiella pneumoniae, P aeruginosa, B fragilis, B thetaiotaomicron, Peptostreptococcus species, Infectious Diseases Society of America (IDSA) recommendations: 2 g IV every 8 hours for 7 to 21 days -Do not use flexible container in series connections. -Complicated infections due to Pseudomonas aeruginosa: 1 g IV every 8 hours MERREM IV should not be mixed with or physically added to solutions containing other drugs. 8 hours (maximum dose is 2 grams every 8 hours), depending on the type of infection (cSSSI, cIAI, intra-abdominal infection or meningitis). Uses: As a single agent therapy for the treatment of complicated skin and skin structure infections due to Staphylococcus aureus (methicillin-susceptible isolates only), Streptococcus pyogenes, S agalactiae, viridans group streptococci, Enterococcus faecalis (vancomycin-susceptible isolates only), P aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis, Peptostreptococcus species, 1 g IV every 8 hours -Pediatric patients younger than 3 months: Administer as IV infusion over 30 minutes. Urinary . There are no established dose recommendations for patients receiving peritoneal dialysis. There is no experience in pediatric patients with renal impairment. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Maximum dose: 2 g/dose -Infants less than 32 weeks gestational age (GA) and postnatal age (PNA) less than 2 weeks: 20 mg/kg IV every 12 hours Complicated skin and skin structure infections, Infants less than 32 weeks GA and PNA less than 2 weeks, Infants less than 32 weeks GA and PNA 2 weeks and older, Infants 32 weeks and older GA and PNA less than 2 weeks, Infants 32 weeks and older GA and PNA 2 weeks and older, For pediatric patients 3 months of age and older, the MERREM IV dose is 10 mg/kg, 20 mg/kg or 40 mg/kg every 8 hours (maximum dose is 2 grams every 8 hours), depending on the type of infection (cSSSI, cIAI, intra-abdominal infection or meningitis). A 20 mg/kg dose of meropenem results in peak serum concentrations of about 50 μg/mL. Pediatric patients: Data not available. Table 1: Recommended MERREM IV Dosage Schedule for Adult Patients with Renal Impairment, Table 2: Recommended MERREM IV Dosage Schedule for Pediatric Patients 3 Months of Age and Older with Normal Renal Function, Table 3: Recommended MERREM IV Dosage Schedule for Pediatric Patients Less than 3 Months of Age with Complicated Intra-abdominal Infections and Normal Renal Function, Table 4: Volume of Sterile Water for Injection for Reconstitution of Injection Vials, We comply with the HONcode standard for trustworthy health information -, Recommended dose (500 mg cSSSI and 1 gram Intra-abdominal). Meropenem Merrem ® - Renal dosing. Shake to dissolve and let stand until clear. -Renal: Renal organ system functions (periodically during prolonged therapy); renal function in elderly patients Approximately 70% of the intravenously administered dose is recovered as unchanged meropenem in the urine over 12 hours, after which little further urinary excretion is detectable. Detailed Meropenem dosage information for adults and children. British National Formulary - BNF (Add filter) 15 October 2020 Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for MEROPENEM WITH VABORBACTAM. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. -Pediatric patients 3 months or older: Administer as IV infusion over about 15 to 30 minutes or as an IV bolus injection over about 3 to 5 minutes; limited safety data available to support use of a 40 mg/kg (maximum of 2 g) bolus dose. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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